- Apr 1 Jesse Stone, American R&B pianist, songwriter (Shake, Rattle and Roll), arranger, and record producer, dies at 97
- Apr 1 Red Flaherty, American baseball umpire (World Series 1955, 58, 65, 70; MLB All Star games 1956, 61, 69), dies from stroke-related complications at 81
- Apr 2 Andrew Gardner, British newscaster (News at Ten), dies in flight en route to Madeira at 66
- Apr 3 Lionel Bart, English pop and theatrical music composer (Oliver), and writer, dies of liver cancer at 68
- Apr 4 Aldus Roger, American Cajun accordionist (Lafayette Playboys - "Les Haricots Sont Pas Salés"), dies at 84
- Apr 4 Early Wynn, Baseball Hall of Fame pitcher (Cy Young Award 1959 Chicago WS; MLB wins leader 1954, 59; 9 x MLB All Star; Cleveland Indians), dies of a stroke at 79
- Apr 4 Faith Domergue, American actress and early "scream queen" (Vendetta, House of 7 Corpses), dies at 74
- Apr 5 Paul David, French Canadian cardiologist (b. 1919)
- Apr 6 Gene Benson, American baseball outfielder (Negro League All-Star 1940, 45-46), dies at 85
- Apr 6 Red Norvo [Kenneth Norville], American jazz vibraphonist known as "Mr. Swing" (Congo Blues; Knockin' on Wood), dies at 91
- Apr 6 William Pleeth, British cellist and teacher (of Jacqueline du Pré), dies of leukemia at 83
- Apr 7 Angus Paton, English civil engineer (wrote economic and infrastructure reports for Canada and Syria, hydroelectric dams), dies at 93
- Apr 9 Ibrahim Baré Maïnassara, Niger politician and general, assassinated at 49
- Apr 10 Heinz Fraenkel-Conrat, German-born biochemist (b. 1910)
- Apr 10 Jean Vander Pyl, American voice, radio and film actress (The Flintstones, The Jetsons), dies of lung cancer at 79
- Apr 12 Boxcar Willie [Travis Martin], American soldier (USAF) and singer ("King Of The Road"), dies of leukemia at 67
- Apr 13 Ortvin Sarapu, New Zealand chess player, dies at 74
- Apr 13 Willi Stoph, German politician (Prime Minister of German Democratic Republic, 1964-73 and 1976-89), dies at 84
- Apr 14 Anthony Newley, British actor and singer-songwriter (Doctor Dolittle; Goldfinger theme; Willy Wonka score), dies at 67
- Apr 14 Bill Wendell, American TV announcer (To Tell The Truth, 1972-77; Late Night With David Letterman; Late Show With David Letterman, 1993-95), dies at 75
- Apr 14 Ellen Corby [Hansen], American actress (The Waltons, Vertigo, Caged), dies of natural causes at 87
- Apr 15 Harvey Postlethwaite, British engineer and racing car designer, dies at 55
- Apr 16 Alexander "Skip" Spence, Canadian-American guitarist, singer and songwriter (Jefferson Airplane), dies of lung cancer at 52
- Apr 16 Laurence Kirwan, British archaeologist (Sudan and Egyptian Nubia), dies at 91
- Apr 16 Nicholas Cayzer, British shipping magnate (British and Commonwealth Shipping), dies at 89
- Apr 18 Gian-Carlo Rota, Italian-born American mathematician & philosopher, dies at 66
- Apr 19 David Sanes, US Navy employee
- Apr 19 Hermine Braunsteiner, Nazi war criminal and female camp guard at Ravensbrück and Majdanek concentration camps, dies at 79
- Apr 20 "Ravishing" Rick Rude, American professional wrestler, dies at 40
- Apr 20 Eric Harris, American mass murderer (Columbine High School shooter), dies at 18
- Apr 20 Señor Wences, Spanish ventriloquist (his hand acts as a puppet) and comedian, dies at 103
- Apr 20 Victims and shooters of the Columbine High School massacre
- Apr 21 Charles "Buddy" Rogers, American film actor (Wings), singer, and dance bandleader, dies at 94
- Apr 22 Apostolos Nikolaidis, Greek singer (first Greek artist to record or re-record the authentic, "prohibited" rebetika songs in the early 1970s with their original lyrics), dies at 60
- Apr 22 Bert Remsen, American actor (Mario-It's a Living), dies at 74
- Apr 22 Chan Canasta, Polish-born magician & mindreader, dies at 79
- Apr 23 Melba Liston, American jazz trombonist, arranger, and composer, dies at 73
- Apr 23 Tullio Pandolfini, Italian water polo athlete (Olympic gold, 1948), dies at 84
- Apr 25 Michael Morris, 3rd Baron Killanin, Irish journalist, author, sports official and 6th President of the International Olympic Committee (1972-80), dies at 84
- Apr 25 Roger Troutman, American funk musician (Zapp), dies during his brother's apparent murder-suicide at 47
- Apr 26 Adrian Borland, English musician (The Sound), dies at 41
- Apr 26 Jill Dando, British television presenter (Crimewatch), shot and killed outside her house at 37
- Apr 27 Al Hirt, American jazz trumpeter (Greatest Horn in the World), dies of liver failure at 76
- Apr 27 Cyril Washbrook, English cricket batsman (37 Tests, 6 x 100, HS 195; Lancashire CCC), dies at 84
- Apr 28 Alf Ramsey, English football manager, dies at 79
Apr 28 American physicist who shared the 1981 Nobel Prize in Physics for his pioneering work with lasers, dies of leukemia at 77
- Apr 28 Rory Calhoun [Francis Timothy McCown], American actor (Blue & Gray, How to Marry a Millionaire), dies of emphysema at 76
- Apr 28 Walter Gieseler, German composer, dies at 79
- Apr 29 Léon Barzin, Belgian-American conductor (NY City Ballet, 1948-58), dies at 98
- Apr 29 Perry Ford [Brian Pugh], British pop singer, session musician and songwriter (The Ivy League - "Tossing And Turning"), dies at 65
- Apr 30 Darrell Sweet, British hard rock drummer (Nazareth - "Love Hurts"), dies of a heart attack at a concert soundcheck at 51
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